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Rethinking Transcriptional Activation in the Arabidopsis Circadian Clock

Figure 4

Expression and regulation of the PRR genes.

(A–C) The mRNA levels of PRR9 (solid red), PRR7 (long dashed green), PRR5 (short dashed blue) and TOC1 (dotted black) in the transition from LD to LL. (A) The F2014 model with eight different parameter sets. (B) Experimental data: PRR9 [35], [36], [54], PRR7 [35], [54], [55], PRR5 [29], [55], [56] and TOC1 [53], [57], [58]. (C) The P2012 and P2011 models (thick and thin lines, respectively). (D) Total PRR5 protein level in prr9;prr7 in LD in F2014 (solid black), P2011 (dashed red), P2012 (dotted blue) and experimental data (green triangles [54]). (E) The predicted repression of PRR transcription by CCA1 and LHY, as a multiplicative factor, with colours as in (A–C). (F) PRR9 mRNA in cca1-11;lhy-21 in LD, normalized to the corresponding wt curves in (A–C); colours as in (D) but data from [11]. The peak levels in (A), (C) and (D) were normalized to 1, whereas the levels in (B) were adjusted manually.

Figure 4