Rethinking Transcriptional Activation in the Arabidopsis Circadian Clock
Components of the clock are laid out according to approximate time of peak mRNA expression, clockwise with zeitgeber time 0 (lights on) at the bottom. Yellow and grey boxes indicate proteins that are active primarily during the day and night, respectively. Solid lines indicate transcriptional regulation and dashed lines indicate protein–protein interactions, with arrows for activation and bars for repression or degradation. Additions to the model relative to P2012 are shown in blue. The green line indicates a hypothetical interaction, and the light grey line indicates an interaction that the model predicts to be extremely weak. The light blue boxes show three main modules of the clock, and interactions between them are shown with thick black lines. EC is the evening complex between ELF3, ELF4 and LUX or NOX, and the dark grey line indicates the ELF3-ELF4 complex. Lightning and yellow circles symbolize light input at the transcriptional and post-transcriptional level, respectively. For an alternative version comparing F2014 with P2012  (published 2013), see Figure S1.