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Emergent Biosynthetic Capacity in Simple Microbial Communities

Figure 5

Metabolic reprogramming of M. extorquens that results in ethanol secretion.

Major reprogrammed fluxes (compared to the mono-culture settings) are plotted. In this example, acetate that was secreted to the medium by S. oneidensis, was taken up by M. extorquens and converted into acetylCoA, leading to increased fluxes in the TCA cycle. A small portion of the acquired acetate was converted into ethanol through acetaldehyde to replenish NAD+ and to facilitate energy production by the TCA cycle. Abbreviations - etoh: ethanol; acald: acetaldehyde; ac: acetate; accoa: acetyl-CoA; cit: citrate; icit: Isocitrate; akg: 2-oxoglutarate; succoa: succinyl-CoA; succ: succinate; fum: fumarate; mal-L: L-malate; oaa: oxaloacetate; NAD: nicotinamide adenine dinucleotide.

Figure 5