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Optimizing Metabolite Production Using Periodic Oscillations

Figure 3

PEP concentration gains by oscillating individual enzymes.

A comparison of the increase in total PEP concentration as a result of oscillating each of the indicated enzymes. The enzymes were oscillated by describing their levels as a cosine function and optimizing the properties of each wave. Gain in PEP levels is measured as a ratio of the total PEP concentration in the oscillating case over the total PEP concentration in the time invariant case. All optimizations were run over an 8

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1003658.g003