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Exploration of the Dynamic Properties of Protein Complexes Predicted from Spatially Constrained Protein-Protein Interaction Networks

Figure 4

A: The experimental DHFR-pca interaction network.

Arp3 was not included in the Tassarov et al. analysis and DHFR-pca edges are not available. Edges for Arp3 are based in predictions from the Arp2/3 structure (blue) and protein interaction data from BIOGRID (pink). B: Principal Component Analysis (PCA) was performed on the set of all conformations to project each conformation on to the two first principal components. Two clusters are formed: major (top) and minor (bottom). C: Biplot for the PCA. The biplot creates a visual representation of the contribution of each variable to the first two principal components. The length and direction of each line associated to each variable indicates its importance in the separation of the data. The PCA landscape indicates the presence of 5 different sub-regions. D: PCA scores were grouped in to a 2D histogram with sub-regions indicated. In parenthesis: number of conformations in sub-region.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1003654.g004