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Exploration of the Dynamic Properties of Protein Complexes Predicted from Spatially Constrained Protein-Protein Interaction Networks

Figure 3

Applying MCMC-PCA2 to a simple toy model.

A: The input data for a toy model. Let A interact with B, B with C, but that A does not interact with C. B: The toy model should satisfy these constraints, as determined by the DHFR-pca. C: The surface-to-surface distance between interacting pairs are modeled as Weibull distributions. This allows D: The surface-to-surface distance between non-interacting pairs is modeled as a cumulative Weibull distribution.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1003654.g003