Predicting the Responses of Repetitively Firing Neurons to Current Noise
Figure 2
Responses of STN neurons to pulsed current noise.
A. Autonomous firing of a STN neuron recorded in the absence of injected noise (upper panel) and in the presence of contiguous 1 ms current pulses (middle panel). The current injected is shown in the bottom panel. The standard deviation of the noise in this example was 90 pA. Average firing rate was unchanged. B. Histogram showing the distribution of noise pulse amplitudes. C. Higher resolution of the injected current (lower panel) and the membrane potential response to currents (upper panel) in the same cell. The capacitative transient at pulse onset and offset is restricted to a single sample (0.05 ms), the membrane changes are almost entirely capacitative and series resistance is well-compensated. D. Changes in regularity of firing during application of the same noise shown in A–C, as indicated by the autocorrelation histogram in the absence (upper panel) and the presence (lower panel) of noise. E. An example showing dependence of interspike interval CV qualitatively similar to those predicted from the phase model, for noise amplitude, pulse duration and baseline firing rate.