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Finding Novel Molecular Connections between Developmental Processes and Disease

Figure 6

The VEGF pathway and its relevance to both BPD hypotheses.

The relationships shown here are derived from the VEGF, PI3K-AKT, mTOR, and HIF-1 signaling pathways and the “Pathways in Cancer” map in the KEGG Pathway database. Dashed lines represent indirect regulation. Genes highlighted in orange are the five lung development genes implicated in ROP.

Figure 6