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Finding Novel Molecular Connections between Developmental Processes and Disease

Figure 1

Pooling genes across related diseases to assess enrichment.

a) Lung development genes linked directly to three related MeSH terms. The genes associated with each term are shown in a different color. b) By pooling the lung development genes from the subtree rooted at the Neural tube defects node, we obtain enough genes to identify significant enrichment at that node. Colors, the same as those in part a, indicate the disease terms with which the genes were associated before pooling.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1003578.g001