Mathematical Modeling of the Phoenix Rising Pathway
Figure 9
Effects of silencing iPLA2 expression on model simulated [PGE2] in wild type MEF cells at 48 hours post radiation.
Experimentally, silencing gene expression can be achieved through treatment of cells with small interfering RNA molecules. In this study, silencing iPLA2 expression was mathematically modeled through reducing k−5 (unit: µM min−1), the rate of iPLA2 synthesis.