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The Free Energy Landscape of Dimerization of a Membrane Protein, NanC

Figure 2

Potentials of mean force for four orientational configurations of the NanC proteins.

The four combinations are for angles of: ; ; ; and (in A, B, C, and D, respectively). The PMFs have depths of (A); (B); (C); and (D). In B, the minimum, labelled , and the two local minima, labelled and , correspond to inter-protein separations at which different numbers of lipids can optimally occupy the intervening region between the two proteins, as explained in the main text and illustrated in Figure 3.

Figure 2