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Phosphorelays Provide Tunable Signal Processing Capabilities for the Cell

Figure 2

Cartoon representations of the four topologies that allowed sigmoidal signal-response relationships in a significant part (more than 2%) of the sampled parameter space when considering monofunctional HK and different total protein concentrations at different layers (see also Table 1, Figure S1 and Supporting Text S3).

Panels A, B, C and D show topologies 14, 16, 30 and 32 respectively, each corresponding to a specific set of reverse phosphotransfer and hydrolysis reactions being present. Reactions are shown as directional arrows, where thickness of the arrow indicates the relative strength of the reaction. In other words, arrows are weighted by the mean reaction rate constant obtained from all sampled parameter sets producing sigmoidality. For each layer and a given topology, a gray (open) backdrop indicates that the mean of total protein concentration at that layer is high (low), based on all sampled parameter sets producing sigmoidal signal-response curves (see Supporting Text S5 for actual mean parameter values and concentrations).

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003322.g002