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A Dendritic Mechanism for Decoding Traveling Waves: Principles and Applications to Motor Cortex

Figure 3

Gabor filtering by excitatory and inhibitory receptor densities.

(A) Density profiles for excitatory (blue) and inhibitory (red) receptor populations which combine to form a Gabor filter (black). In this case, the excitatory density was nominated as Gaussian. (B) Spatial frequency response of the Gabor filter. Peaks correspond to waves of length 300 µm. (C) Excitatory (blue) and inhibitory (red) receptor samples taken from the density distributions in panel A. The combined receptor field (blue+red) represents the dendritic field of the neuron. (D) Spatial frequency response of the combined receptor field. Peaks correspond to vertically oriented waves of length 300 µm. (E) The combined receptor field superimposed on its preferred wave pattern. The wave pattern propagates from left to right at 6 mm/sec to simulate 20 Hz oscillations in the cortical field. (F) Time course of the net excitatory (blue shading) and inhibitory (red shading) conductances in response the preferred wave pattern. Faint lines show individual post-synaptic conductances for n = 40 randomly selected receptors (not to scale). Each receptor fires 20 spikes/sec on average. Heavy black line shows the dendritic current induced by the net changes in conductance. The amplitude of the dendritic current is modulated as the wave propagates across the receptor field. (G) The combined receptor field superimposed on the orthogonal wave pattern which propagates from top to bottom at 6 mm/sec. (H) Time course of the dendritic response to the orthogonal wave pattern. In this case the wave pattern does not modulate the dendritic current even though the individual receptors still fire at 20 spikes/sec on average.

Figure 3