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Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools

Figure 2

Shadow prices anticorrelate with experimental measurements of growth limitation.

Metabolites exhibiting were experimentally determined to be growth-limiting. Growth-limitation and shadow prices in FBA are significantly anticorrelated under all nutrient limitations from [21]. To make the data more comparable across different nutrient limitations, the data is plotted on a log scale. All points to the left of the grey bar have a shadow price of zero. All correlations for this data (calculated using a linear scale, not the log scale depicted in the Figure) are reported in Table S1. Abbreviations: 6PDG, 6-phospho-d-gluconate; ADE, Adenosine; ALA, Alanine; ARG, Arginine; ATP, ATP; CHO, Choline; CTP, CTP; CYD, Cytidine; CYT, Cytosine; DHAP, Dihydroxyacetone-Phosphate; DOG, Deoxyguanosine; DS7P, D-sedoheptulose-7-phosphate; F16P, Fructose-1,6-bisphosphate; GLN, Glutamine; GLU, Glutamate; GUA, Guanosine; HIS, Histidine; INO, Inosine; LEU, Leucine/isoleucine; LYS, Lysine; NAD, NAD+; NAG1P, N-acetyl-glucosamine-1-phosphate; NIC, Nicotinate; ORN, Ornithine; PHP, Phenylpyruvate; PYR, Pyruvate; RIBP, Ribose-phosphate; SER, Serine; SUC, Sucrose; THR, Threonine; TRE, Trehalose; TRP, Tryptophan; UDPG, UDP-D-glucose; UTP, UTP. For clarity, only cytosolic metabolites from the metabolic model are plotted.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003195.g002