Statistical Analysis of Molecular Signal Recording
Continuous decoding to estimate sequences of eight concentrations over 20 minutes of recording using varying numbers of templates. The 95% confidence interval of the estimated concentrations (light red) that result from the decoding algorithm presented here on an ion concentration input sequence representing the word “RECORDER” (dark red). Concentrations are mapped to letters via A = 0/25, B = 1/25,,…,Z = 25/25, so that the concentration sequence representing the word RECORDER is 17/25, 4/25…). The numbers of templates used were, from top to bottom, 1000, 100, 10, and 1. For all panels, kinetic parameters are those of DNAP ( ms, ms, ), , and ().