Statistical Analysis of Molecular Signal Recording
A) Example time-varying ion concentration signal. In a neuron, peaks in calcium concentration occur during neural firing. B) Example products from the simultaneous replication of multiple template strands, showing correct (C) and incorrect (I) nucleotide additions, with the time of incorporation shown on the horizontal axis. Misincorporations are more likely in the presence of higher ion concentration. C) The misincorporation counts from each template copy are summed to calculate the misincorporation probability at every nucleotide position in the template. In this example, approximately 100 nucleotides are replicated per second on average.