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Bacteria-Human Somatic Cell Lateral Gene Transfer Is Enriched in Cancer Samples

Figure 3

Identification of HPV Integration into the HeLA genome.

As a control, integrations of the human papillomavirus genome NC_001357 (red) into the HeLa cell genome represented by hg19 (blue) were detected with our pipeline. The integration of HPV into chromosome 8 in the HeLa genome is supported by read pairs with one read mapping to HPV and the other mapping to the human genome (purple lines). The log-transformed coverage of the reads supporting integration (purple histogram, axis minimum = 0, axis maximum = 4) is consistent with the known integration of the HPV E6 and E7 genes shown in pink on the HPV genome. The log-transformed coverage of the viral mate pairs is also shown (red histogram).

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1003107.g003