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The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum

Figure 5

Measures of optimality and predictability after adaptation of gene knockouts on glucose for ∼600–800 generations.

A,B) The % optimality of the ancestor (black) and evolved isolates (grey); C,D) distance to optimal flux distribution for FBA-predictions based upon BM/S (A,C) or ATP/S (B,D).

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1003091.g005