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The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum

Figure 2

Evolved changes in central carbon metabolism for the LTEE populations after 50,000 generations of adaptation on glucose.

A) The flux pathways measured for the LTEE lines are denoted with numbers and red arrows. The genes knocked out in the knockout data set and the entry point of lactate into the network are both indicated. B) A heat map of the difference between evolved and ancestral flux ratios from the LTEE populations. The right side indicates flux ratios predicted for the ancestral line according to each optimality criterion. The number of the flux ratio corresponds to the numbered pathways in A. Single asterisks denote significant changes as calculated by ANOVA, double asterisks are also significant by Tukey-HD.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003091.g002