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Inferring Metabolic States in Uncharacterized Environments Using Gene-Expression Measurements

Figure 6

Predicted tricarboxylic acid cycle fluxes in YPEtOH cultures.

The network of mitochondrial and cytosolic tricarboxylic acid cycle reactions is shown. The thickness of the arrows is drawn in proportion to the predicted fluxes. Acetaldehyde is predicted to be the main energy source and grey arrows indicate an alternative route through which ethanol could be used as energy source. In the cytosol a network of non-TCA reactions (glutamate decarboxylase, 4-aminobutyrate transaminase, succinate semialdehyde dehydrogenase, and aspartate transaminase) that convert oxaloacetate and glutamate into succinate and asparate with concomitant production of and NADPH is shown as a single arrow. Metabolite abbreviations: AcAld (acetaldehyde), Asp (aspartate), Cit (citrate), Fum (fumarate), Glu (glutamate), Glx (glyoxylate), Mal (malate), Oaa (oxaloacetate), Succ (succinate).

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1002988.g006