The Timing and Targeting of Treatment in Influenza Pandemics Influences the Emergence of Resistance in Structured Populations
Panel a shows the final size for wild-type, resistant and both infections as a function of percentage treated, , for targeted (dashed lines) and non-targeted (solid lines) treatment regimes. We see a transition from wild-type to resistant infections at a lower treatment percentage in the targeted treatment regime. Panel b shows the percent of total infection that is the resistant strain for the targeted (dashed line) and non-targeted (solid line) treatment. Parameters: , , , , and .