The Timing and Targeting of Treatment in Influenza Pandemics Influences the Emergence of Resistance in Structured Populations
Effects of treatment when initial conditions are above (panels b, c, d) and below (panels e, f, g) the critical manifold. Panel a is replicated from Figure 2, with each dot corresponding to the panels at right. Solid lines correspond to mean-field approximations, and points correspond to means of 100,000 simulations on networks of size 250,000. Horizontal black line corresponds to a mean of 1 infected individual in a network of 250,000 over 100,000 simulations. With no treatment the disease reaches a maximum and decays (panels b and e). Treatment is only effective early in the simulations when the initial conditions are under the critical manifold (panel f compared to panel c) as opposed to when the initial conditions are over the critical manifold (panel g compared to panel d). Parameters: , , , , , , and .