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The Timing and Targeting of Treatment in Influenza Pandemics Influences the Emergence of Resistance in Structured Populations

Figure 2

Final epidemic size and demonstration of the critical manifold.

Results of the mean-field approximations. Panel a shows the final infected proportion as a function of for all infections () (red line), wild-type without treatment () (black line) and wild-type without mutation () (blue line). Panel b demonstrates the critical manifold leading to dependence on initial conditions (dashed grey line). Treatment in the red region (“Dangerous Treatment”) results in emergence of resistance, while treatment in the green region (“Efficient Treatment”) can lead to eradication. Parameters: .

Figure 2