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Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective

Figure 4

Enzyme group dependencies, of those enzymes that function alone and in pairs, for the optimization of myristoyl-CoA.

Boxes indicate those enzymes that can work alone while the ovals are those enzymes that require one other enzyme to increase myristoyl-CoA production. Those enzymes in blue are increased while those in red are decreased. Darkened lines indicate the dependency groups which produce at least 90% of maximum output of myristoyl-CoA. A. Enzyme group dependencies for optimization using a flat redirection coefficient library. B. Enzyme group dependencies using a sensitivity redirection coefficient library.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1002882.g004