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Chapter 6: Structural Variation and Medical Genomics

Figure 7

Mutation, selection, and clonal expansion in tumor development leads to genomic heterogeneity between cells in a tumor.

Current DNA sequencing approaches sequence DNA from many cells and thus result in a heterogenous mixture of mutations, with varying numbers of both passenger mutations (black) and driver mutations (red).

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1002821.g007