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Weakly Circadian Cells Improve Resynchrony

Figure 3

Networks with more weak oscillators resynchronize better.

We measured the synchronization index (SI) of the modeled population in the coupled (days 1–6), TTX-uncoupled (days 7–12), and recovery (days 13–18) conditions and compare the results across different population and network configurations. We show the effects of varying the percentage of strong oscillators (top row) and of varying the network topology (bottom row). For each configuration-type, we run 56 simulations. (A) The mean SI is shown over time for populations of 0% (cyan), 20%, 35%, 50%, 65%, 80%, and 100% (magenta) strong cells. (B) For each simulation, we compute the mean SI for days 3 to 5 after the wash (days 15 to 18). Here we show the mean and standard deviation across simulations using the same color scheme. (C) We simulated all networks with 50% strong cells and show the mean SI is shown for populations with weak cells at hubs (squares), both strong and weak cells placed randomly at hubs (circles), and strong cells at hubs (triangles) The effect of network configuration on quality of synchrony is shown in (D) and is labeled by the type of cell at network hubs.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1002787.g003