Modeling Protective Anti-Tumor Immunity via Preventative Cancer Vaccines Using a Hybrid Agent-based and Delay Differential Equation Approach
Figure 6
Time plots of tumor and CTL populations from a simulation of the ABM-DDE system.
(left) Tumor antigenicity . All other parameters are taken from the base values shown in Table 1. The tumor population is extinct on day 213. (right) Plot of the cube root and natural logarithm of the tumor population from day 190 to extinction. The numerical solution of
has a high linear correlation
, implying that
decays as a cubic function of
. (The linear regression is
.) On the other hand, the numerical solution of
does not exhibit linear behavior, showing that
does not decay exponentially.