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Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

Figure 3

Representative conformations from the peaks of the P(Rg) plot, along with their Rg values.

Appearing next to the Rg values of each conformation is the fraction of the best-fit ensemble made up by that conformation. For all conformations the SH3 domain appears in yellow, the SH2 domain appears in red, the N-lobe of the kinase domain appears in blue, the C-lobe of the kinase domain appears in orange, and the domain-domain linkers appear in cyan.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1002695.g003