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Model-Free Reconstruction of Excitatory Neuronal Connectivity from Calcium Imaging Signals

Figure 1

Network activity in simulation and experiments.

A Bright field image (left panel) of a region of a neuronal culture at day in vitro 12, together with its corresponding fluorescence image (right panel), integrated over 200 frames. Round objects are cell bodies of neurons. B Examples of real (left) and simulated (right) calcium fluorescence time series, vertically shifted for clarity. C Corresponding averages over the whole population of neurons. D Distribution of population-averaged fluorescence amplitude for the complete time series, from a real network (left) and a simulated one (right).

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1002653.g001