Viral Perturbations of Host Networks Reflect Disease Etiology
A, Viral proteins (virome) interact with host proteins (viral targets) in the host interactome, which in turn are linked to various human diseases (phenome) through mutations in particular disease susceptibility genes (variome). B, Determining topological proximity between viral targets and genes associated with virally implicated diseases by measuring the shortest path lengths between them. For each disease, the minimum number of hops of interactions needed to connect any of its associated genes to any viral targets is designated as the shortest path. C,D, The average shortest path for either EBV (C) or HPV16 (D) was significantly shorter than random expectation.