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Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT

Figure 4

Example of a metabolic sub-network that was identified as being significantly more present in cancer tissues compared to their corresponding healthy tissues.

Aminoacetone, which is a toxic by-product of amino acid catabolism, is converted to toxic methylglyoxal in a reaction that also result in hydrogen peroxide. The toxicity of methylglyoxal is relieved by two reaction steps involving ligation to glutathione and resulting in lactic acid. The generated hydrogen peroxide is taken care of by the enzyme biliverdin reductase. This is an example of how network-based analysis can lead to a more mechanistic interpretation of data.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1002518.g004