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Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

Figure 7

Discovered drug-target, target-disease and disease-gene associations network.

Grey arrows denote the old drug-target interactions, grey edges denote the old target-disease associations and blue edges denote the known disease-gene associations, which were extracted from DrugBank, Online Mendelian Inheritance in Man (OMIM) Morbid Map and literature reports (The further data were given in Table S7). Red arrows among approved drug nodes (cyan circle) and target nodes (yellow squares) denote the new discovered drug-target interactions in this study. Red dotted edges denote new target-disease associations discovered in this study. Cyan circle: drug node, red square: on-target (Primary targets annotated in DrugBank), grey square: off-target, yellow square: new off-target (new discovered target for a given drug validated in this study), violet square: disease node, green regular hexagon: gene. The graph was prepared by Cytoscape (http://www.cytoscape.org/).

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1002503.g007