Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference
The drug–target (DT) bipartite network, in which a drug node (circle) and a target node (square) are connected to each other by grey edge if the target is annotated to have known experimental interactions with the drug in DrugBank.
The DT network was generated using known FDA-approved small molecule DT interactions. The size of the drug node is the fraction of the number of targets that the drug linked in DrugBank. The size of the target node is the fraction of the number of drugs that the target linked in DrugBank. Color codes are given in the legend. Drug nodes (circles) are colored according to their Anatomical Therapeutic Chemical Classification. The graph was prepared by Cytoscape (http://www.cytoscape.org/).