Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis
Figure 8
Variability in cell fate and time-to-death depends on the interplay between multiple factors.
(A) Plots of tMOMP as a function of Bcl-2 level for three levels of Bax (0.3X [Bax]0, left, 1X [Bax]0, center, and 3X [Bax]0, right) and Bid (0.1X [Bid]0, blue, 1X [Bid]0, green, and 10X [Bid]0, red). Orange shading represents the 5th and 95th percentiles of the measured distribution of endogenous Bcl-2 in HeLa cells. (B) Histograms of the tMOMP distributions in the range of endogenous Bcl-2 (indicated by the orange shading) for varying Bid and Bax levels. For panels A and B, initial concentrations of Bcl-2 were sampled uniformly in the exponent between 102 to 107 molecules per cell and all other proteins concentrations were set at their default mean values (Table S2 in Text S3).