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Evolution of the Multi-Domain Structures of Virulence Genes in the Human Malaria Parasite, Plasmodium falciparum

Figure 6

Evolution of gene associations.

a) Simulated timeseries of the different genotypes grouped by the degree of diversities of their defining genes shows an evolutionary advantage and dominance of genotypes whose genes have different levels of diversity (low-high or high-low). b) Heat map of the long-term average frequency distribution of all possible types (taken from the last 30 years of the timeseries in a) showing significantly higher representation of genotypes with different gene diversities. c) Bar graph of the long-term (30 year) average gene diversity associations from all 400 variants in the population showing a negative association between the level of diversity of one gene and diversity at the second gene.

Figure 6