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Circular Permutation in Proteins

Figure 1

Schematic representation of a circular permutation in two proteins.

The first protein (outer circle) has the sequence a-b-c. After the permutation the second protein (inner circle) has the sequence c-a-b. The letters N and C indicate the location of the amino- and carboxy-termini of the protein sequences and how their positions change relative to each other.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1002445.g001