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Adhesion Failures Determine the Pattern of Choroidal Neovascularization in the Eye: A Computer Simulation Study

Figure 8

Snapshots of a simulation replica with stable Type 1 CNV.

3D visualization of a simulation replica exhibiting Stable Type 1 CNV over one simulated year (adhesion scenario ID: 38, simulation ID: 902) (RRl = 3, RRp = 3, RBl = 2, RBp = 2, ROl = 3). Snapshots of the simulation at months 3 (A), 6 (B), 9 (C) and 12 (D). (A) Stalk cells (black arrows) invade the sub-RPE space through a hole (black outline arrow) in BrM (light blue outline arrow) that the tip cell opens during the first 24 hours. Brown outline arrow shows the RPE cells. Red outline arrow shows the CC (B, C) Stalk cells proliferate until they fill the sub-RPE space in month 9, after which proliferation slows down (D) The 45 stalk cells form a connected capillary network in the sub-RPE space. Cell type colors: 1) POS and PIS: light purple, 2) RPE: brown, 3) Stalk cells: green, 4) Vascular cells (CC): red, 5) BrM: light blue. Scale bar ∼50 µm. We have rendered the boundaries of individual cells as semi-transparent membranes. POS, PIS and RPE cells are more transparent to show the underlying structures. See also Video S1.

Figure 8

doi: https://doi.org/10.1371/journal.pcbi.1002440.g008