Adhesion Failures Determine the Pattern of Choroidal Neovascularization in the Eye: A Computer Simulation Study
3D plot of the regression-inferred average (1−MW) using 10 simulation replicas for each adhesion scenario in the 3D parameter space obtained by setting RRp = RRl and RBp = RBl. The average (1−MW) shows the stalk cell locus even when CNV fails to initiate, so a region prone to ET2 CNV, develops ET2 CNV only if CNV initiates. Red corresponds to (1−MW) = 1 and purple corresponds to (1−MW) = 0. The black region at the top-back corner indicates the locus of normal adhesion. The three isosurfaces correspond to (1−MW) = 0.25 (right), 0.5 (middle) and 0.90 (left). The five adhesion parameters and their (multi)linear combinations account for 93% of the observed variance in average MW for all 108 adhesion scenarios (R2 = 0.89). The red region with (1−MW)>0.9, can be divided into three sub-regions: 1) When RPE-RPE junctional adhesion is normal, RPE-BrM junctional adhesion is moderately impaired, and RPE-POS labile adhesion is severely impaired (weak). 2) When RPE-RPE junctional adhesion is severely impaired (weak) and RPE-BrM junctional adhesion is normal, independent of RPE-POS labile adhesion. 3) When RPE-RPE adhesion is weak, RPE-BrM adhesion is moderately to severely impaired, and RPE-POS adhesion is severely impaired. The red region does not include all adhesion scenarios in Table S3 leading to Early Type 2 CNV. To show the structure of the isosurfaces, we have rotated the axes relative to Figure 3.