Novel Approach to Meta-Analysis of Microarray Datasets Reveals Muscle Remodeling-related Drug Targets and Biomarkers in Duchenne Muscular Dystrophy
Most of SNEA-derived regulators of down-regulated genes regulate the processes related to myotube formation, fast-to-slow fiber type switch (including changes in myofiber composition, mitochondria content and insulin sensitivity) and metabolic changes in DMD affected muscles. Relations are described in text. Catalytic subunit of AMPK, PRKAA2, is shown next to AMPK. Functional class - class of proteins, such as enzyme families. Complex - a group of two or more proteins linked by non-covalent protein-protein interactions. Expression - protein members of one class regulate expression of proteins in another class. DirectRegulation - protein members of one class bind and regulate proteins in another class. Regulation - protein members of one class indirectly regulate proteins in another class. ProteinModification - protein members of the regulator class phosphorylate or otherwise modify proteins in the target class. PromoterBinding - protein members of one class bind promoters of genes encoding proteins in another class.