Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome
Figure 3
Metabolic modules differentially present or abundant in at least one body habitat of the human microbiome.
Metabolic modules and pathways from the KEGG BRITE hierarchy [26] found to be differentially abundant (inner cladogram) or differentially covered (outer ring, presence/absence) in the human microbiome. The former were determined using LEfSe [23] and the latter by presence in at least 90% of samples with ≥0.9 coverage or absence in at least 90% with ≤0.1 coverage. Differentially abundant modules are colored by their most abundant body habitat. 168 significantly enriched module abundances were detected, in contrast to only 24 differentially covered.