Using Functional Signatures to Identify Repositioned Drugs for Breast, Myelogenous Leukemia and Prostate Cancer
Figure 1
The comparison of up- or down-regulated genes between each pair of the gene-expression signature from the CMAP and the gene-expression signature from the GEO.
The parameter k indicates the preselected number of up- or down-regulated genes. UC (Top ranking genes in a Cancer type) and UB (Top ranking genes with a Bioactive compound) represent up-regulated genes in the GEO and the CMAP respectively, whereas DC (Botom ranking genes in a Cancer type) and DB (Bottom ranking gene with a Bioactive compound) represent down-regulated genes in the GEO and the CMAPs respectively.