Joint Modelling of Confounding Factors and Prominent Genetic Regulators Provides Increased Accuracy in Genetical Genomics Studies
(a,b): number of cis and trans associations found by alternative methods as a function of the chosen FDR cutoff. (c) Inflation factors of alternative methods, defined as . (d) Consistency of calling cis associations between two independent glucose yeast eQTL datasets. (e) Consistency of calling eQTL hotspots between two independent glucose yeast datasets, where SNPs are ordered by the extent of trans regulation as determined by .