Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
(A) DPQ matrix with AMP and PLP sites, plus the locations for the segment 1–20 in GPb (P1) and GPa (P2). (B) Structure of GPa (1gpa). The segment 1–20 that moves upon phosphorylation of Ser14 is green in the GPb form and red in the GPa form. The slightly hidden coenzyme PLP and the substrate GLS are drawn as yellow spheres. (C) and (D) Two views of the coupling DPi between active site and the rest of the protein. The color scheme for DPi is the same as in Figure 4.