Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
All 3D structures in this paper were drawn with PyMol. (A) Structure of PFK (PDB entry 3pfk). The effector ADP is drawn with orange spheres, and the substrate F6P with yellow spheres, ligand coordinates were taken from PBD entry 4pfk. (B) Leverage coupling DPi between ADP site of one chain (lower right ADP) and the rest of the protein. The surface is colored in a gradient from cyan to magenta where cyan represents the lowest measured value of DPi and magenta the highest value. (C) Same as (B) but for one of the F6P sites (lower right one).