Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication
(A) The matrix measuring similarity between leverage profiles for different normal modes μ and ν, for 4 of the proteins studied. The magnitude of the leverage profiles are also plotted to indicate which are the most important modes. (B) The total leverage profile and the three most important individual leverage profiles for AdK (Λ1, Λ2, and Λ3). The average total binding leverage for the residues at the active site are indicated by black circles.