A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation
(A) A group of Core cells breaks through an adjacent EphA4 or ephrinB2 compartment, leading to fused somites. Somite fusing is a defective phenotype that does not occur in normal in vivo or in silico somitogenesis. (B) A single Core cell is stranded in the naturally acellular perisomitic ECM. Such stranded cells occasionally occur in normal in vivo somitogenesis. Cell colors are the same as in Figure 5. Scale bar 40 µm. For more information see RESULTS: The segmentation-clock period and PSM growth rate regulate somite size.