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A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation

Figure 6

Segmentation-clock period versus Wnt3a concentration in simulated PSM.

(A) Segmentation-clock period versus Wnt3a concentration in the simulated PSM (red squares and blue circles) and for cells with a constant Wnt3a concentration (connected black squares with error bars). (B) Segmentation-clock period as a function of cell position along the AP axis, measured by the anterior distance from the posterior (right) end of the simulated PSM. Slower oscillations in the anterior (left) simulated PSM are consistent with similar observations in vivo [77]. Red squares indicate the period measured between times of minimum Lfng concentration and blue circles indicate the period measured between times of maximum Lfng concentration. Parameters are the same as in the reference simulation (Figure 7). For more information see METHODS: Coupling segmentation clock to the morphogen fields.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1002155.g006