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Binding Leverage as a Molecular Basis for Allosteric Regulation

Figure 8

Analysis of phosphofructokinase (PFK) using LLF10.

(A) Two views of the tetrameric structure. Blue spheres represent the activator ADP and red spheres the substrate F6P. Protein coordinates were taken from PDB entry 3pfk, coordinates for F6P from 4pfk, and for PGA from 6pfk. (B) Same views as in (A) but now showing the surface colored by fi(0.22). (C) Latent sites can be seen in a slightly rotated version of the left half of (B). (D) ROC curves.

Figure 8