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Binding Leverage as a Molecular Basis for Allosteric Regulation

Figure 1

A basic model for allostery.

The top left panel shows an enzyme that is allosterically inhibited by ligand binding: the inhibition takes place by stabilization of an inactive conformation. The top right panel shows a putative free energy landscape for this process. The transition from the active to inhibited state can follow one of two main paths, either induced fit (green) or conformational selection (red). The bottom panels show allosteric activation for the same protein. With the geometry of the illustration there will be a large barrier for induced fit, as indicated in the bottom right free energy landscape.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1002148.g001