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Conflicting Biomedical Assumptions for Mathematical Modeling: The Case of Cancer Metastasis

Figure 7

Three hypothetical scenarios involving five experts, each providing a story containing five stages.

The three scenarios illustrate situations of (A) “complete agreement”, (B) “moderate agreement”, and (C) “random agreement.” Panels D, E and F illustrate the probability of agreement and disagreement between two randomly chosen experts on at least k statements for each scenario (see Figure 4B). Panels G, H and I render heat maps to illustrate the transition probability matrices after a single Markov chain transition under each scenario. Each stochastic matrix is square, non-negative and organized in the following way. The ith row of the matrix provides probabilities of transitions from state i to all other states of the model. The sum of probabilities in each row is therefore equal to 1.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1002132.g007